THE ROLE OF SUPERVISED LEARNING IN ENHANCING DIAGNOSTIC ACCURACY OF NEURODEGENERATIVE DISEASES
Keywords:
Supervised Learning, Neurodegenerative Diseases, Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease, Machine Learning, SVM, Random Forest, Neural Networks, Medical Imaging, Early Diagnosis, Feature Selection, Diagnostic AccuracyAbstract
Neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases, are characterized by progressive neural degeneration, leading to cognitive and motor impairment. Early diagnosis is critical for effective management and improving patient outcomes, yet traditional diagnostic methods often lack sensitivity in detecting early-stage disease. This study explores the role of supervised learning techniques in enhancing diagnostic accuracy for neurodegenerative diseases. By reviewing key supervised learning models such as support vector machines (SVMs), random forests, and neural networks, this paper evaluates their effectiveness in analyzing complex medical datasets, including MRI, PET scans, and genetic data. The results demonstrate that supervised learning models significantly improve diagnostic accuracy, particularly in early detection. However, challenges such as data availability, overfitting, and ethical concerns must be addressed to ensure widespread clinical application. This paper also presents a comparative analysis of different models, highlighting their performance in terms of accuracy, precision, recall, and F1 scores. The findings underscore the transformative potential of machine learning in neurodegenerative disease diagnostics and suggest directions for future research to overcome existing limitations.
References
Arbabshirani, M. R., Plis, S., Sui, J., Calhoun, V. D., & Fujimoto, K. (2017). Single subject prediction of brain disorders in neuroimaging: Promises and pitfalls. NeuroImage, 145, 137-165. https://doi.org/10.1016/j.neuroimage.2016.02.079
Bron, E. E., Smits, M., van der Flier, W. M., Vrenken, H., Barkhof, F., Scheltens, P. & van Ginneken, B. (2015). Standardized evaluation of algorithms for computer-aided diagnosis of dementia based on structural MRI: The CADDementia challenge. NeuroImage, 111, 562-579. https://doi.org/10.1016/j.neuroimage.2015.01.048
Klöppel, S., Stonnington, C. M., Chu, C., Draganski, B., Scahill, R. I., Rohrer, J. D.& Ashburner, J. (2008). Automatic classification of MR scans in Alzheimer's disease. Brain, 131(3), 681-689. https://doi.org/10.1093/brain/awm319
Orru, G., Conversano, C., Hitchcott, P. K., & Pettersson-Yeo, W. (2012). Machine learning in neuroimaging: A systematic review. Neuroscience & Biobehavioral Reviews, 36(1), 1101-1105. https://doi.org/10.1016/j.neubiorev.2011.12.003
Sørensen, L., Igel, C., Liv Hansen, N., Osler, M., Lauritzen, M., Rostrup, E., & Nielsen, M. (2016). Early detection of Alzheimer’s disease using MRI hippocampal texture. Human Brain Mapping, 37(3), 1148-1161. https://doi.org/10.1002/hbm.23091
Zhang, D., Wang, Y., Zhou, L., Yuan, H., & Shen, D. (2011). Multimodal classification of Alzheimer’s disease and mild cognitive impairment. NeuroImage, 55(3), 856-867. https://doi.org/10.1016/j.neuroimage.2011.01.008
Dyrba, M., Grothe, M., Kirste, T., & Teipel, S. J. (2015). Multimodal analysis of functional and structural disconnection in Alzheimer’s disease using multiple kernel SVM. Human Brain Mapping, 36(6), 2118-2131.
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Copyright (c) 2020 Ashwin Narasimha Murthy, Souptik Sen, Ramesh Krishnamaneni (Author)

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